Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusionBerbamine 염산염은 S 단백질 매개 막 융합을 차단하여 SARS-CoV-2 감염을 강력하게 억제합니다Article Published on 2022-04-252022-09-11 Journal: PLoS Neglected Tropical Diseases [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral activity antiviral agent Antiviral compounds antiviral drug antiviral drugs approved berbamine caused cell lines Clinical treatment COVID-19 drug effort experiment global pandemic global public health host cells Infection inhibit inhibit SARS-CoV-2 membrane fusion molecular docking outbreak Protein S-mediated cell-cell fusion SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S2 severity subunit tested viral entry viral spike virus entry [DOI] 10.1371/journal.pntd.0010363 PMC 바로가기 [Article Type] Article
A Five-Helix-Based SARS-CoV-2 Fusion Inhibitor Targeting Heptad Repeat 2 Domain against SARS-CoV-2 and Its Variants of ConcernSARS-CoV-2 및 우려 변종에 대한 헵타드 반복 2 도메인을 표적으로 하는 5개 나선 기반 SARS-CoV-2 융합 억제제Article Published on 2022-03-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] 5-Helix acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 cell-cell fusion concern conserved conserved region Coronavirus-2 COVID-19 vaccines Delta delta variant domain Efficacy fusion fusion inhibitor helix heptad repeat heptad repeat 1 heptad repeat 2 homologous Infection inhibited Lambda nCoV omicron Omicron variants pandemic Prevent Prophylactic Protective Protein pseudotyped SARS-CoV-2 Recombinant protein Repeat S-mediated cell-cell fusion S2 subunit SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 six-helix bundle targeting therapeutic treat variant Variant of concern. variants variants of concern variants of interest VoC VOCs wild-type [DOI] 10.3390/v14030597 PMC 바로가기 [Article Type] Article
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusionSARS-CoV-2 스파이크의 푸린 절단은 감염 및 세포-세포 융합을 촉진하지만 필수적이지는 않습니다Research Article Published on 2021-01-252022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, [키워드] ACE2 ACE2 receptor activate activated acute respiratory syndrome coronavirus Amino acid Antiviral antiviral therapies attachment binding Cell cell-cell fusion cells cellular protease cellular proteases cleavage cleaved cocktail coronavirus COVID-19 pandemic CRISPR CRISPR-Cas9 Donor drug focus furin furin cleavage furin inhibitor furin inhibitors furin knockout cell furin knockout cells furin protease fusion fusion peptide host cell host cell membrane host cell receptor infect infected cell Infection inhibitor inhibitors motif multibasic site multinucleated cells mutant Mutation peptide pre-activation Prevent promote protease protease TMPRSS2 Protein reduce reduces required Research respiratory responsible reveal S protein S-mediated cell-cell fusion SARS-CoV-2 SARS-CoV-2 antiviral therapy SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread syncytia formation target cell the S protein the SARS-CoV-2 thought TMPRSS2 TMPRSS2 protease treat triggered triggering unique Viral viral infection Viral protein viral spread virus virus entry virus entry process virus-host membrane fusion [DOI] 10.1371/journal.ppat.1009246 PMC 바로가기 [Article Type] Research Article